Disease …
Heart …
Cancer …
Elderly …
Quartile 1 had the lowest average cholesterol and the highest mortality:
Quartile 1: 149mg%
Quartile 2: 178mg%
Quartile 3: 199mg%
Quartile 4: 232mg%
The other quartiles showed no benefit among them from lower cholesterol either.
Refining …
TABLE 2— Percentages of Vitamin C Deficiency (<11
µmol/L), Depletion (11–28 µmol/L), and
(Figure from Hampl)
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Risk …
Insulin …
Diabetes …
Number of Persons with Diagnosed Diabetes in the United States, 1980–2004. NEJM 2/9/2006;354(6):545-548
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|
|
Hepatic fructose metabolism: A highly lipogenic pathway. Fructose is readily
absorbed from the diet and rapidly metabolized principally in the liver.
Fructose can provide carbon atoms for both the glycerol and the acyl portions
of triglyceride. Fructose is thus a highly efficient inducer of de novo lipogenesis.
High concentrations of fructose can serve as a relatively unregulated source
of acetyl CoA. In contrast to glucose, dietary fructose does NOT stimulate
insulin or leptin (which are both important regulators of energy intake and
body adiposity). Stimulated triglyceride synthesis is likely to lead to
hepatic accumulation of triglyceride, which has been shown to reduce hepatic
insulin sensitivity, as well as increased formation of VLDL particles due to
higher substrate availability, increased apoB stability, and higher MTP, the
critical factor in VLDL assembly. (Basciano 2005) |
KNa …
Rice diet …
Robinson K et al, Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 11/15/95; 92(10):2825-30 redrawn by Dr Glenn Tisman
Survival …
Data from Nygard et al, Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease. NEJM 1997; 337(4):230-6, redrawn by Dr Glenn Tisman
MgCa …
CRP
…
NAC
…
NAC treatment for 8 weeks safely replenishes whole blood GSH and T cell GSH in HIV-infected individuals. Thus, NAC offers useful adjunct therapy to increase protection against oxidative stress, improve immune system function and increase detoxification of acetaminophen and other drugs. These findings suggest that NAC therapy could be valuable in other clinical situations in which GSH deficiency or oxidative stress plays a role in disease pathology, e.g. rheumatoid arthritis, Parkinson's disease, hepatitis, liver cirrhosis, septic shock and diabetes. (Eur J Clin Invest 2000; 30:915-29).
CRP …
hs-CRP plotted against quartiles of dietary total antioxidant capacity; the relationship was even stronger among hypertensive subjects. The P for trend is 0.005, meaning that this result is unlikely to be due to chance.
(Brighenti F et al, Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects. Br J Nutr 2005; 93:619-625)
(Finch
C et al, Inflammatory Exposure and Historical Changes in Human Life-Spans. Science 2004;
305: 1736‑9)
Cholesterol & E …
Plasma C …
